Flexible polymer heart valves are promising clinical prostheses for replacement of diseased or malfunctioned natural heart valves. However, the flexible polymer leaflets are prone to fatigue fracture, which hinders their practicality in clinical applicati Flexible polymer heart valves are promising clinical prostheses for replacement of diseased or malfunctioned natural heart valves. However, the flexible polymer leaflets are prone to fatigue fracture, which hinders their practicality in clinical applicati